Having in mind that in chronic kidney disease the GSTM1 is normally up-regulated in a protective response to increased oxidative stress, as well as that the GSTM1 could be a surrogate for unmeasured oxidative stress markers [17,23], it seems reasonable to assume that this genetic variant may be deleterious in terms of carotid atherosclerosis and consequent stroke in ESRD patients. This evidence concerns the gene GSTM1 and stroke disorder.