Among the molecular pathways altered in tumor cells harboring KSHV, or following KSHV de-novo infection is phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) [13,14], which is an ubiquitous pathway that controls cell survival and cell metabolism [15,16]. The gene discussed is AKT1; the disease is neoplasm.