TNF and neoplasm: Although LCL85 does not effectively sensitize Colon 26 cells to FasL-induced apoptosis, LCL85 is effective in suppressing Colon 26 cell metastatic potential in vivo, suggesting that other host factors, such as IFN-γ and TNFα secreted by T cells, might also act to sensitize the tumor cells to apoptosis in vivo, which requires further study.