Multivariate Cox regression analysis enrolling above-mentioned significant parameters showed that NUCB2 protein expression (P < 0.001), PCa stage (P < 0.001), Gleason score (P < 0.001), and preoperative PSA (P < 0.001) were independent prognostic factors for overall survival of patients with PCa. Here, NUCB2 is linked to posterior cortical atrophy.