MAPK3 and cancer: Although the mechanism of cell malignant transformation or cell proliferation induced by FAS over expression in malignant tumor is not fully understood, several mechanisms including increasing expression of epidermal growth factor receptor and activation of PI3K/AKT and ERK1/2 signaling pathways, and the modulation and nuclear maturation of the transcription factor sterol regulatory element-binding protein 1c have been reported [1-3].