CD274 and Crohn disease: GWAS results showed that a SNP substitution mutation of BBS9 was associated with amyotrophic lateral sclerosis [33]; furthermore, BANF2, SNX25, SAMD12 and GPR177 were associated with Crohn’s disease [34], and inflammatory bowel disease was associated with the upregulation of human CD274 at the cell surface from macrophage-derived dendritic cells of the inflamed colon [35].