The study revealed that depth of invasion (P=0.007), lymph node (P = 0.009) and distant metastasis (P = 0.01), TNM stage (P = 0.008), expression of L1CAM (P = 0.007), and of EPCAM (P = 0.009) were independent prognostic factors in patients with gastric carcinoma. The gene discussed is L1CAM; the disease is gastric carcinoma.