L1CAM was overexpressed in esophageal adenocarcinoma [11], pancreatic cancer [12,13], colorectal cancer [14], gallbladder carcinoma [15], extrahepatic cholangiocarcinoma [16], gastric cancer [17], and cholangiocarcinoma [18], notably at the invasive front of the tumors. The gene discussed is L1CAM; the disease is familial pancreatic carcinoma.