CARD6 and neoplasm: The cytoplasmic microbial sensors NOD receptors 1 and 2 (NOD1 and NOD2) were also expressed at lower levels in tumor tissues (p = 0.0025 and p = 0.0029, respectively), along with downstream signaling molecules for innate microbial sensors including CARD6, CARD9 and TRAF6 (p = 0.0207, p = 0.0040 and p = 0.0119, respectively) (Figure 3b).