Furthermore, p28gankyrin binds multiple proteins and plays roles in diverse pathways such as NFκB, AKT/PI3K/HIF1α, MDM2, ß-catenin or c-Myc affecting cell proliferation, apoptosis and hypoxia response, or HCC invasiveness and metastasis [106,107,108,109]. This evidence concerns the gene AKT1 and hepatocellular carcinoma.