Like cyclin E, cyclin A and cyclin B1 integrate deregulations of the pRb pathway but are also under the control of other transcriptional regulators such as B-Myb or ZHX2 for cyclin A [165,185] or FoxM1 for cyclin B1 [186], which are found frequently deregulated in HCC (Figure 6). This evidence concerns the gene RB1 and hepatocellular carcinoma.