Given the important involvement of the PI3K/AKT pathway in the pathogenesis of tumors, and given the paucity of datas regarding CNV in PI3K/AKT gene members in DLBCL, we first investigated CNVs using NanoString nCounter’s method [13] in 12 members of the PI3K/AKT signaling pathway in human DLBCL using an nCounter CNV assay. This evidence concerns the gene PIK3CA and diffuse large B-cell lymphoma.