Previous studies have reported that the phosphatidylinositol 3-kinase (PI3K) signaling pathway plays a critical role in regulating the growth and survival of DLBCL cells [3], and that constitutive phosphorylation of PI3K resulted in the activation of signaling that represented frequent events both for main pathway components and their downstream substrates [4]. The gene discussed is PIK3CG; the disease is diffuse large B-cell lymphoma.