In contrast, another study in colon cancer cells LS174T, demonstrated that over-expression of wild-type Rab5 resulted in recycling P-gp from the plasma membrane into intracellular compartments, suggesting that Rab5 regulates P-gp endocytosis instead of exocytosis (13), however, this study did not investigate the polarization status of the cell culture of LS174T, which is shown to be polarized in normal culture condition (46). This evidence concerns the gene RAB5A and malignant colon neoplasm.