ADM and bacterial infectious disease: In addition, many genes related to the response to bacterial infection and lipopolysaccharide (LPS) were up-regulated in patients such as NFKBIA, FOS, PTGS2 (encoding prostaglandin-endoperoxide synthase 2), ADM (encoding adrenomedullin), SOCS3 (encoding suppressor of cytokine signaling 3), TRIB1 (encoding tribbles homolog 1) and IL1B. Among them, FOS, PTGS2 and IL1B are genes involved in “response to glucocorticoid stimulus”, which was also enriched in the up-regulated genes and likely reflected treatment effect.