In addition, using FLS derived from the synovium of RA patients, it has been reported that downregulation of galectin-3 expression by galectin-3 siRNA inhibited spontaneous and LPS-induced secretion of inflammatory cytokine IL-6, further suggesting the potential of targeting galectin-3 in the suppression of joint inflammation [102]. This evidence concerns the gene LGALS3 and rheumatoid arthritis.