CD4 and Opportunistic infection: The mechanisms of how the functional antioxidant enzyme confers better protection for HIV disease severity is not known at this time; our studies with antioxidants [18,38,39] and those of others [40,41] indicate that, while the primary effect may be on the viral burden, the observed benefit on CD4 cell count is consistent, with previous studies showing a direct relationship between serum antioxidants and CD4 cell count [42,43], opportunistic infections, disease progression, and HIV-related mortality [44–46].