Recently, it was demonstrated by a combination of in vivo and in vitro studies that Aβ binding to the cellular prion protein (PrPc), an oligomer-specific high-affinity binding site for Aβ, can play a central role in Aβ-induced memory deficits, axon degeneration, synapse loss, and neuronal death in the AD brain through Fyn kinase activation [40]. This evidence concerns the gene PRNP and Alzheimer disease.