There is an impressive list of genes and proteins involved in AD pathologies including APP, presenilins, secretases, kinases, and phosphatases all touted as being responsible for either increasing the production of the neurotoxic Aβ protein or promoting the hyperphosphorylation of CRMP-2 or tau, leading to the devastating neurodegenerative sequelae. Here, MAPT is linked to Alzheimer disease.