In some literatures, various associated disorders of gingival enlargement had been discussed that include Zimmermann Laband syndrome (ear, nose, bone, and nail defects with hepatosplenomegaly), Rutherford syndrome (oculodental syndrome), Jones syndrome (progressive deafness), Cross syndrome (microphthalmia, mental retardation, athetosis, and hypopigmentation), Murray-Puretic Drescher syndrome (juvenile hyaline fibromas), and Ramon syndrome reasons, [9, 14–16], that is, why HGF is considered as part and parcel of multisystem syndrome [2, 10]. The gene discussed is HGF; the disease is Zimmermann-Laband syndrome.