Table 1 defines directly downregulated targets validated by luciferase reporter assays as determined by TarBase [30]. Particularly, the downregulation of PU.1 by miR-155 may be of relevance in CLL as multiple studies have identified a correlation between PU.1 and lymphoid tumourigenesis [34]. The gene discussed is SPI1; the disease is B-cell chronic lymphocytic leukemia.