Upregulation of miR-24 in AML patients with t(8; 21) is thought to be caused by binding of the AML-ETO fusion product to the miRNA gene locus, and overexpression leads to the downregulation of mitogen-activated protein kinase phosphatase 7 (MPK7) [58]. The gene discussed is RUNX1T1; the disease is acute myeloid leukemia.