To validate this interesting concept and to decipher the molecular consequences of non-IG aberrations of FOXP1 in general, we performed comprehensive genetic and molecular investigations of four lymphoma cases with non-IG rearrangements of FOXP1 and compared these with cases harboring t(3;14)(p13;q32)/IGH-FOXP1 and FOXP1-positive DLBCL with no apparent structural aberrations of the gene. Here, FOXP1 is linked to lymphoma.