Lack of DPP4 activity acts to decrease myocardial infarct size, stabilize the cardiac electrophysiological state during myocardial ischemia, reduce ischemia/reperfusion injury, and prevent left ventricular remodeling after myocardial infarction [14], [15], [19], [20]. The gene discussed is DPP4; the disease is myocardial infarction.