GATA4 can be presumed to act as an anti-apoptotic factor, by protecting human GCT cells from apoptosis induced by e.g. TRAIL (Tumor Necrosis Factor Apoptosis Inducing Ligand) [27], and by activating an essential apoptosis inhibitor BCL2 in non-human cell models [26], [28]. This evidence concerns the gene GATA4 and granular cell tumor.