C1GALT1 and colitis: In contrast to a previous study in which TM-IEC C1galt-/- mice developed intestinal inflammation ten days after induced loss of core 1-derived O-glycans [17], TM-IEC C1galt-/- mice in our animal facility did not develop spontaneous colitis or show any signs of inflammation ten days (Fig. 1A, left panels) or even up to 26 weeks after knockout induction.