In contrast to our previously published data that show marked effects in retinopathy associated with the lack of Sirt1[12], our results here reveal that a genetically increased dosage of Sirt1 in either neurons or vessels within the mouse retina does not alter vaso-obliteration, pathologic neovascularization, or neuronal degeneration in oxygen-induced retinopathy. The gene discussed is SIRT1; the disease is retinal disorder.