Previously, we found that Sirt1 is significantly upregulated in oxygen-induced retinopathy and conditional depletion of Sirt1 in retinal neurons significantly dampens vascular regrowth and precipitates pathologic neovascularization in retinopathy[12], suggesting that endogenous Sirt1 induction is important for protecting against retinopathy development. The gene discussed is SIRT1; the disease is retinal disorder.