SIRT1 and retinal disorder: There is also no significant difference in pathologic neovascularization (control: 7.89±0.70% vs. Nes-Sirt1OE: 8.62±0.48%, n = 15–20/group, p = 0.38, Fig. 2c,e), suggesting that increasing Sirt1 levels in retinal neurons is not advantageous in protecting against oxygen-induced retinopathy.