[14] The most distinctive aspects of Tax-tumors were conserved even in the absence of IL-15 including splenomegaly, osteolytic bone lesions, a predominant admixture of tumor infiltrating Ly6G+ neutrophils (FIG. 1D), and constitutive NFκB activity within the malignant LGLs (FIG. 1E). This evidence concerns the gene NFKB1 and neoplasm.