EPAS1 and adenoma: Cluster #7 (differentiating inflammation from adenoma and carcinoma from adenoma) contains 3 TFs out of 54 regulators: EPAS1 (endothelial PAS domain protein 1), ETV4 (ets variant 4), CITED2 (Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2), and different factors, ECM and membrane proteins, like CYR61, matrix metallopeptidases, different PDGFs, PDGFRs, etc. The processes related to the activity of these regulators are vascularization, cell survival and cell migration.