This observation is in agreement with the paper [48] where authors have shown that the expression of the "angiogenesis" gene set is significantly increased in CRCs compared to adenomas and that the increased mRNA expression levels of PDGFRB (changed in 8.7% of adenocarcinoma cases [46] according to cBioPortal) can be used as a tumor biomarker. The gene discussed is PDGFRB; the disease is adenocarcinoma.