The final state (SS4) presents with hypercortisolism, suppressed TEST and a shift towards the Th1 immune response (low T2Cell, T2Cyt, GnRH, LH/FSH and TEST/EST, and high CORT, GRD, GR, T1Cyt and T1Cell). This evidence concerns the gene PLOD1 and adrenal gland hyperfunction.