The dental phenotype of the Rsk2-/Y mouse resembles that encountered in the tabby mouse (a model for X-linked hypohidrotic ectodermal dysplasia- an ectodermal dysplasia characterized by an absence or dystrophic development of hair, nail, sweat- lacrymal- mammary- glands and tooth; OMIM #305100). Here, RPS6KA3 is linked to ectodermal dysplasia syndrome.