ANGPT2 and acute myeloid leukemia: However, OS and RFS were not influenced by high versus low Ang2 and FIS1 expression in CN-AML (Ang2, OS: hazard ratio (HR) 1.046; 95% confidence interval (CI), 0.657–1.665; P = 0.851; RFS: HR, 1.471; 95% CI, 0.714–3.029; P = 0.295.