FLT3 and leukemia: The BPR1J-340 compound exhibits potent FLT3 inhibitory activity, with a 50% inhibitory concentration (IC50) of 25±5 nM and growth inhibitory effects on FLT3-ITD+ leukemia MOLM-13 and MV4;11 cells with a GC50 value of 3.4±1.5 and 2.8±1.2 nM, respectively.