More notably, up-regulation of Wnt-1 expression has been shown to positively correlate with tumor proliferation stimulated by HCV core protein [24], and recently, its prognostic role in HCV-related HCC has been demonstrated [26], which is consistent with our findings that down-regulation of miR-152 is associated with a more proliferative HCC phenotype. This evidence concerns the gene WNT1 and neoplasm.