Additionally, miR-152 has been reported to be an tumor suppressive miRNA that is silenced by DNA hypermethylation in endometrial cancer, and restoration of miR-152 expression in endometrial cancer cell lines was sufficient to inhibit tumor cell growth in vitro and in vivo, with E2F3, MET, and Rictor being its novel candidate targets [20]. The gene discussed is E2F3; the disease is endometrial cancer.