DS4.3 (RIMRILRILKLAR) is a newly identified CPP peptide derived from S5 subunit of a voltage-gated potassium channel (Kv2.1) (see below, manuscript in preparation [34], [35]).In the present study, the DS4.3-MTD chimeric protein deployed by an attenuated Salmonella typhimurium was found to be effective both in vitro and in vivo against experimental tumor models. The gene discussed is KCNB1; the disease is neoplasm.