Since then, many members of the TNF superfamily have been shown to participate in obesity related diseases, including TNF-related apoptosis inducing ligand (TRAIL) (4), B cell activating factor (BAFF) (5), Lymphotoxin-α (LTα) (6, 7), Lymphotoxin β receptor (LTβR) (8), and Tumor necrosis factor ligand superfamily member 14 (TNFSF14) (9) among others. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.