HCRT and Genetic obesity: The relative functional significance of orexins in controlling energy homeostasis and food intake by acting both in the brain and periphery (Heinonen et al., 2008) has remained elusive but orexin peptide or OXR levels appear to be regulated under a variety of nutritional conditions such as food deprivation, sweetener-induced overconsumption and genetic obesity (Mondal et al., 1999; Karteris et al., 2005; Furudono et al., 2006).