The unaltered glucose homeostasis observed with chronic ACT-335827 treatment in CAF diet fed rats with existing glucose imbalance contrasts with the improved fasting glucose levels seen in obese OXR-1 deficient mice (Funato et al., 2009) and in ob/ob female mice chronically treated with a high dose of the preferential OXR-1 antagonist SB-334867 before obesity onset (Haynes et al., 2002). This evidence concerns the gene OXR1 and obesity due to melanocortin 4 receptor deficiency.