No cysts were observed in Azi1 null kidneys aged 6 months or older (n = 6, Figure S5D–F), nor was any obesity observed in aged Azi1Gt/Gt mice (n = 8 at 3 months, n = 5 at 6 months, Figure S5G and H). The gene discussed is CEP131; the disease is obesity due to melanocortin 4 receptor deficiency.