This model is also compatible with the ability of C/EBPα to transdifferentiate lymphoid cell types into macrophages [54], [55], with the observation that a subclass of leukemia patients with silenced C/EBPα expression develops AML associated with distinct T-cell characteristics [56] and with the finding that pre-leukemic Cebpa mutant GMPs readily differentiate into T-cells [57]. The gene discussed is CEBPA; the disease is leukemia.