Interestingly, however, the frequency of malaria-specific CD4+ T cells producing any TNFα was inversely associated with the monthly prevalence of asymptomatic parasitemia, even after controlling for duration since last episode of malaria and/or cumulative prior malaria episodes (PRR 0.41 per 10 fold increase, P = 0.011). The gene discussed is CD4; the disease is parasitic infectious disease.