CD4 and malaria: We observed a strong inverse correlation between the frequency of IFNγ+/IL-10+/TNFα− CD4+ T cells and the duration since the last episode of malaria (Spearman's Rho = −0.39, P<0.001, Fig. 3d), with more recent malaria associated with a higher frequency of these co-producing cells, as well as a positive correlation with the total cumulative number of prior episodes (Spearman's Rho = 0.23, P = 0.04, Fig. 3e).