APOE and inherited lipid metabolism disorder: Several mechanisms have been outlined for the association between ART and dyslipidaemia, including reduced synthesis of cis-9-retinoic acid, leading to dysregulation of adipocyte differentiation and apoptosis, increased hepatic TG synthesis,81 increase in dense LDL particles, a shift towards TG-rich VLDL and increase in apolipoprotein C-III- and apolipoprotein E-containing particles.