However, a decrease in HER2 IHC score was observed only in SCH specimens with a 24-h delay to fixation, whereas the HER2/CEP17 ratio of FISH in SCH was decreased from 2.3 to 1.3 if the tumor sample was left at room temperature for only 6 h before fixation. Here, ERBB2 is linked to spindle cell hemangioma.