LEPR and Hypertension: The resistin (RETN) gene, located on 19p12.2, has been associated with T2DM in several prospective epidemiological studies across a wide variety of population groups, but results have been conflicting [27] Studies on biological function, epidemiology, and genetics, indicate that ADIPOQ, LEPR, and RETN may be associated with T2DM and hypertension.