Intriguingly, a significant interaction was identified between two SNPs rs13306519 in LEPR and rs266729 in ADIPOQ for both T2DM (P_int = 0.012, OR_int = 2.67) and hypertension (P_int = 0.0041, OR_int = 2.23), suggesting that individuals carrying variants of both genes might have a higher risk of developing T2DM and hypertension than those carrying variants in single genes. The gene discussed is LEPR; the disease is Hypertension.