CD8A and T-cell large granular lymphocyte leukemia: Furthermore, the TCRα chain might have an important role next to the TCRβ chain, especially in the initial phase of high-affinity clonal TCR selection.30 However, the CDR3 regions of the TCRα (TCRA) genes have not been extensively studied in CD8+/TCRαβ+ T-LGL leukemia.