CD8A and T-cell large granular lymphocyte leukemia: On the basis of our findings, we did not find straightforward evidence for common (super)antigen involvement in the pathogenesis of CD8+/TCRαβ+ T-LGL leukemia, since no immunodominant clones with identical or highly similar TCRA and TCRB CDR3 amino-acid sequences could be identified in a majority of patients.