In CD8+/TCRαβ+ T-LGL leukemia non-random clonal selection has been suggested,18, 29 even though no consistent single structural homologous motif could be detected in CDR3 sequences of TCRβ (TCRB) genes, The seeming lack of such identical TCR specificities could however also be explained by the diverse HLA background of these patients. The gene discussed is CD8A; the disease is T-cell large granular lymphocyte leukemia.