Likewise, complete sequencing of TCRA gene rearrangements has only been performed in few (n=5) T-LGL leukemia patients, thus far not showing any signs of common Vα or Jα gene usage.42 In our cohort of 22 patients, we could not detect preferential Vα or Jα gene usage; moreover, TCRA CDR3 sequence analysis did not show a common amino-acid motif between the various patients, which is thus in line with the TCRB results. The gene discussed is COX5A; the disease is T-cell large granular lymphocyte leukemia.