Interestingly, highly similar CDR3 sequences could also be detected in TCRγ (TCRG) and TCRδ (TCRD) genes in nearly half of patients diagnosed with TCRγδ+ T-LGL leukemia, supporting a common antigen-driven origin of this disorder.16 The gene discussed is TRGC1; the disease is T-cell large granular lymphocyte leukemia.