To compare the relative frequencies of associated cytopenias, autoimmune disorders and malignancies in all three types of T-LGL leukemia, we analyzed the clinical data of our CD8+ T-LGL cohort (n=26) and the data of 56 CD8+ T-LGL leukemia patients described by Wlodarski et al.29 and compared those with the clinical features of 36 patients with CD4+ T-LGL leukemia28 and our cohort of 44 published16 and 19 novel TCRγδ+ T-LGL leukemia patients. The gene discussed is CD8A; the disease is autoimmune disease.