NR4A1 and neoplasm: HDAC inhibitors have been reported to induce expression of the orphan receptor gene NUR77 in vitro, a tumor suppressor gene known to cause rapidly fatal AML when deleted in mice and which is commonly silenced in human AML blasts.29, 30 Changes in Nur77 mRNA expression in peripheral blood mononuclear cells during cycle 1 were assessed in 29 patients.