Whereas STAT3 is heavily linked with chronic disease progression and cancer, this is often influenced by a signaling crosstalk with some other transcriptional regulators (Bollrath et al., 2009, Grivennikov et al., 2009, Jenkins et al., 2005, Jenkins et al., 2007, Judd et al., 2006, Nowell et al., 2009). The gene discussed is STAT3; the disease is cancer.