The CSC hypothesis has also been coined for HNSCC in the head and neck; some cell surface markers have been reported as CSC markers in HNSCC cancers, such as CD44, CD133, ALDH1 and ABCG2[5-7], and high expression of these markers is usually considered an indicator of poor prognosis. Here, PROM1 is linked to head and neck squamous cell carcinoma.