In consideration of the clinical features, CD44 expression was also associated with larger tumor size (RR = 1.39, 95% CI 1.17 - 1.64) and lymph node metastasis (RR = 1.98, 95% CI 1.33 - 2.95) in pharyngolaryngeal cancer of Asian patients; however, this phenomenon was not found in European patients, which may due to the limited number of European articles. Here, CD44 is linked to neoplasm.