Abdominal obesity promotes increased secretion of a range of metabolites and of biologically active substances, including glycerol, FFA, inflammatory mediators (e.g. tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6)), plasminogen activator inhibitor-1 (PAI-1) and C-reactive protein [65-67]. The gene discussed is SERPINE1; the disease is Abdominal obesity.