The PSA level (P < 0.001), PV (P < 0.001), PSAD (P < 0.001), f/t (P < 0.001), and the rates of abnormal DRE (P < 0.001) findings and hypoechoic masses detected using TRUS (P < 0.001) differed significantly between the cancer and the non-cancer groups (Table 2). The gene discussed is KLK3; the disease is cancer.