INS and diabetes mellitus: Therefore, using a non-insulin-dependent streptozotocin (STZ) DM animal model that develops insensate neuropathy, the purpose of this investigation was to examine in parallel the development of DSPN and DM-associated changes in cardiac structure and function, as well as potential mechanisms, such as autonomic dysfunction, evaluated by changes in urinary and myocardial NE content and myocardial neuronal markers.