Sub-acute infection could be predicted in patients without clinical or paraclinical (white blood cell count (WBC) and CRP) signs of infection in the acute period by: 1) an increased HFnorm (normalized high frequency power), but a reduced LFnorm (normalized low frequency power) as well as a reduced LF/HF ratio during the day for all parameters, and 2) a reduced LF (low frequency power) and VLF (very low frequency power) at night (all changes p < 0.05)[25]. This evidence concerns the gene CRP and infection.