The aims of the present study were to describe the trend in dialysate IL-6 concentration and IL-6 appearance rate (IL-6 AR) in incident PD patients, to explore the utility of dialysate IL-6 as a predictor of PSTR and peritonitis in this patient group and to evaluate the impact of neutral pH, low GDP PD solutions on these outcomes. The gene discussed is IL6; the disease is peritonitis.