SCRIB and neoplasm: By overexpressing an activated Ras (Rasv12) in the Drosophila eye imaginal disk and screening for the entire Drosophila genome, Pagliarini and Xu indentified Scrib as the promoting factor for the metastatic transformation of the otherwise benign tumor caused by overexpression of Ras oncogene alone (Pagliarini and Xu, 2003).