TNF and neoplasm: Under the condition of established tumor, the Drosophila haemocyte could be recruited to the tumor site and tumor associated haemocytes are the major source of Drosphila TNFα, Eiger, to promote the growth and invasion of the tumor cells into other tissues (Cordero et al., 2010), while a TNF-dependent mechanism in Drosophila eliminates cells deficient for the polarity tumor suppressors Scrib or Dlg to maintain the tissue homeostasis and keep any malignant growth in check (Brumby and Richardson, 2003).