RHO and Anxiety: Moreover, the LPA1 receptor activates several intracellular signaling pathways mediated through Rho, Phospholipase C, Ras and Phosphatidylinositol 3-kinase proteins [7], signaling cascades that could regulate the expression of early immediate genes, such as c-Fos [65]–[67], and that have implications for anxiety [68]–[69].