In line with our findings, other substances inhibiting PHD enzymatic activity such as deferoxamine mesylate (DFO), 3,4-dihydroxybenzoate (3,4-DHB) and DMOG have the potential to reduce brain injury upon cerebral ischemia in rodent models of stroke [1], [21], [22], [23], [24]. The gene discussed is PDC; the disease is stroke disorder.